WHAT IS KEMOKARB ?

Kemokarb is an anticancer drug (“antineoplastic” or “cytotoxic”) chemotherapy drug. Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. “Normal” cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition. Cancerous cells lose this ability. Cancer cells no longer have the normal checks and balances in place that control and limit cell division. The process of cell division, whether normal or cancerous cells, is through the cell cycle. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division).

MEDICINE USES :

Carboplatin is used to treat ovarian cancer. It is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous system or germ cell tumors; osteogenic sarcoma; and as preparation for a stem cell or bone marrow transplant.

CARBOPLATIN COMMON SIDE EFFECTS :

nausea, vomiting, loss of appetite; tired feeling; temporary hair loss; or pain, swelling or redness where the medicine was injected.

Call your doctor at once if you have:

    pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
    fever, chills, body aches, flu symptoms, sores in your mouth and throat;
    severe or ongoing vomiting; stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); numbness or tingly feeling in your hands or feet; hearing or vision problems;
    skin changes where the medicine was injected; or low magnesium (confusion, uneven heart rate, jerking muscle movements, muscle weakness or limp feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for KEMOKARB CARBOPLATIN INJECTION :

    Kemokarb may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
    Carboplatin may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
    Do not receive a live vaccine (eg, measles, mumps) while you are taking Carboplatin. Talk with your doctor before you receive any vaccine.
    Lab tests, including complete blood cell counts, may be performed while you use Carboplatin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
    PREGNANCY and BREAST-FEEDING: Carboplatin has been shown to cause harm to the fetus. Avoid becoming pregnant while taking this medicine. It is not known if this medicine is found in breast milk. Do not breast-feed while taking this medicine.

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Unopened vials of Kemokarb Injection are stable for the life indicated on the package when stored at 25°C (77°F) [excursions permitted to 15°- 30°C (59°- 86°F) and protected from light. This injection multidose vials maintain microbial, chemical, and physical stability for up to 15 days at 25°C following multiple needle entries.

DRUG INTERACTIONS :

Some MEDICINES MAY INTERACT with Kemokarb. Tell your health care provider if you are taking any other medicines, especially any of the following:

    Aminoglycoside antibiotics (eg, gentamicin) and anticoagulants (eg, warfarin) because side effects, including risk of bleeding, kidney problems, or hearing problems, may be increased by this medication
    Medicines that may harm the kidney (eg, amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney.

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Active Ingredients: (RS)-3-methyl-2-oxovaleric acid
(?-ketoanalogue to DL-isoleucine), calcium-salt 67 mg
4-methyl-2-oxovaleric acid
(?-ketoanalogue to leucine), calcium-salt 101 mg
2-oxo-3-phenylpropionic acid
(?-ketoanalogue to phenylalanine), calcium-salt 68 mg
3-methyl-2-oxobutyric acid
(?-ketoanalogue to valine), calcium salt 86 mg
(RS)-2-hydroxy-4-methylthio-butyric acid
(?-hydroxyanalogue to DL-methionine), calcium-salt 59 mg
L-lysine acetate 105 mg
L-threonine 53 mg
L-tryptophan 23 mg
L-histidine 38 mg
L-tyrosine 30 mg
Total nitrogen content per tablet 36 mg
Calcium content per tablet 1.25 mmol = 50 mg

WHAT IS LAMIVIR S-40 ?

Lamivudine  belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells. Stavudine belongs to a group of drugs called as nucleoside reverse transcriptase inhibitors (NRTIs). It works by inhibiting multiplication of viruses thus decreasing their levels in the infected patient.

MEDICINE USES :

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection. Stavudine is used in combination with other anti-viral drugs in the treatment of Human Immunodeficiency Virus (HIV) infection.

LAMIVUDINE/STAVUDINE COMMON SIDE EFFECTS :

diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; or abnormal liver function tests.

Some people develop lactic acidosis while taking Lamivudine/Stavudine. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as:

    muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak;
    stomach pain, nausea with vomiting; or fast or uneven heart rate.

Call your doctor at once if you have:

    pancreas problems–severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; or
    liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for LAMIVIR S-40 LAMIVUDINE/STAVUDINE TABLETS :

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

    Avoid drinking alcohol
    Avoid pregnancy
    Consult a doctor if you have liver or kidney disease or metabolic or lactic acidosis or peripheral neuropathy
    Discontinue use if rapid increase in aminotransferase levels, progressive hepatomegaly, or metabolic or lactic acidosis of unknown origin
    Have diabetes and renal impairment
    Pregnancy

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Lamivir S Tablet may interact with the following drugs and products:

    Sulfamethoxazole
    Trimethoprim
    Zidovudine

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

WHAT IS LAMIVIR HBV ?

Lamivir HBV belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV related infections or cancer.

MEDICINE USES :

Cipla Lamivudine is for treating HIV, which causes the acquired immunodeficiency syndrome (AIDS). It is not a cure for HIV or AIDS. It is for treating hepatitis B. It should not be used in people who are infected with both hepatitis B and HIV.

LAMIVUDINE COMMON SIDE EFFECTS :

diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; or abnormal liver function tests.

Some people develop lactic acidosis while taking Lamivudine. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as:

    muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak;
    stomach pain, nausea with vomiting; or fast or uneven heart rate.

Call your doctor at once if you have:

    pancreas problems–severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; or
    liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for LAMIVIR HBV LAMIVUDINE TABLETS :

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: pancreatitis, kidney problems, liver problems (such as hepatitis B or C, cirrhosis), alcohol use.
    Avoid alcoholic beverages because they may increase your risk for liver problems and/or pancreatitis.
    Caution is advised when using this drug in children because they may be more sensitive to the effects of the drug, especially the increased risk of pancreatitis.
    Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, caution is advised when using this drug in older adults because they may be more sensitive to the effects of the drug.
    During pregnancy, this medication should be used only when clearly needed.
    Lamivir HBV passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Drug interactions may change how your medications work or increase your risk for serious side effects. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.