WHAT IS KADCYLA INJECTION?

Kadcyla (ado-trastuzumab emtansine) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Kadcyla is approved to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic breast cancer) after prior treatment with trastuzumab (Herceptin) and a taxane.

USES OF KADCYLA INJECTION:

Kadcyla is used to treat a certain type of breast cancer that has spread to other parts of the body.

Kadcyla is usually given after other cancer medications have been tried without success.

Kadcyla (ado-trastuzumab) should not be used in place of Herceptin (trastuzumab).

POSSIBLE SIDE EFFECTS:

Kadcyla can harm your liver. Call your doctor at once if you have upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Along with its needed effects, ado-trastuzumab emtansine (the active ingredient contained in Kadcyla) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

COMMON SIDE EFFECTS MAY INCLUDE:

This drug has caused very serious (rarely fatal) bleeding. Get medical help right away if you develop symptoms of very serious bleeding, including: weakness on one side of the body, slurred speech, vision changes, confusion, severe stomach/abdominal pain, trouble breathing, vomit that is bloody or looks like coffee grounds, black/tarry stool.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat and cough).

This medication can sometimes cause a serious infusion reaction with serious lung problems. Immediately tell your doctor of the following side effects that occur while this drug is being given or within 24 hours after your treatment is finished, such as chills, fever and flushing, wheezing, shortness of breath, nausea, headache, dizziness, fainting, rash, and weakness.

DRUGS PRECAUTIONS:

Before taking ado-trastuzumab emtansine, tell your doctor or pharmacist if you are allergic to it; or to other mouse protein medications; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: previous cancer treatments (including radiation therapy to the chest), current infection, heart disease, high blood pressure, lung problems and previous severe reaction to monoclonal antibody treatment, liver disease (including a rare liver condition called nodular regenerative hyperplasia).

DRUGS INTERACTIONS:

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Does not start, stop, or change the dosage of any medicines without your doctor’s approval.

If you will be using an anthracycline (such as doxorubicin) after stopping ado-trastuzumabemtansine treatment, if possible, wait at least 7 months.

Other medications can affect the removal of ado-trastuzumab emtansine from your body, which may affect how ado-trastuzumab emtansine works. Examples include azole antifungals (such as itraconazole, ketoconazole), clarithromycin, HIV protease inhibitors (such as atazanavir, ritonavir), nefazodone, telithromycin, among others.

KAMAGRA CHEWABLE TABLETS

Kamagra chewable tablet by Ajanta Pharma is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing and dilating the blood vessels in the lungs. This lowers the blood pressure in the lungs and helps to improve your ability to exercise.

SILDENAFIL CITRATE USES :

Sildenafil Citrate is used for treating high blood pressure in the lungs (pulmonary arterial hypertension [PAH]).

SILDENAFIL CITRATE 100 MG COMMON SIDE EFFECTS :

Diarrhea; dizziness; flushing; headache; mild pain, redness, or swelling at the injection site; muscle aches; nausea; nosebleed; sore throat; stuffy or runny nose; trouble sleeping; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; chest pain; confusion; fainting; fast or irregular heartbeat; fever; memory loss; numbness of an arm or leg; one-sided weakness; painful or prolonged erection; persistent or severe pain, redness, or swelling at the injection site; ringing in the ears; seizure; severe or persistent dizziness or nosebleed; severe or persistent vision changes; shortness of breath; speech problems; sudden decrease or loss of hearing; sudden decrease or loss of vision in one or both eyes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for KAMAGRA SILDENAFIL CITRATE 100 MG TABLETS :

    Kamagra chewable tablets may cause drowsiness, dizziness, fainting, or blurred vision. These effects may be worse if you use it with alcohol or certain medicines. Use this medication with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
    If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
    Kamagra 100 mg may uncommonly cause mild, temporary vision changes (eg, blurred vision, sensitivity to light, blue/green color tint to vision). Contact your doctor if vision changes persist or are severe.
    Sudden decreases in hearing and loss of hearing have been reported in some patients who have taken Sildenafil. Sometimes they also noticed ringing in the ears or dizziness. If you notice a sudden decrease or loss of hearing, contact your doctor right away.
    Do not use medicines or treatments for ED while you are using Sildenafil without first checking with your doctor.
    Sildenafil is not approved for use in children.
    PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using this medicine while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Sildenafil, check with your doctor. Discuss any possible risks to your baby.

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F)

DRUG INTERACTIONS :

Tell your doctor about all your current medicines and any you start or stop using, especially:

    an antibiotic such as clarithromycin, erythromycin, or telithromycin;
    antifungal medicine such as ketoconazole or itraconazole;
    medicine to treat HIV/AIDS, such as atazanavir, indinavir, ritonavir, or saquinavir; or
    drugs to treat high blood pressure or a prostate disorder.

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.