ABOUT TYROGEF

Tyrogef is a type of drug called a tyrosine kinase inhibitor (TKI), also known as a cancer growth inhibitor. Kinases are proteins in the body that regulate how the cells grow and divide. Tyrogef blocks (inhibits) the protein from sending signals to the cancer cells that make them grow and divide.

TYROGEF USES

Tyrogef is used to treat some people with non-small cell lung cancer (NSCLC). It only works for cancers that have an abnormal form of a protein called epidermal growth factor receptor (EGFR). Tests are done on the cancer cells from a lung biopsy or previous surgery to check the level of EGFR.

TYROGEF SIDE EFFECTS :

Acne; diarrhea; dry skin; loss of appetite; mouth ulcers; nausea; unusual weakness; vision problems; vomiting; weight loss.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the eyelids, mouth, face, lips, or tongue); cough; dark urine; dizziness; eye irritation or pain; extreme fatigue; fever; persistent diarrhea; stomach pain; swelling of the ankles or feet; yellowing of the skin or eyes.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

TYROGEF PRECAUTIONS:

    Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
    Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., pulmonary fibrosis), severe kidney disease, eye problems, stomach/intestinal ulcers, other stomach/intestinal problems (such as diverticulitis, blockage, bowel disease), smoking, cancer that has spread to the bowels.
    Gefitinib is not recommended for use during pregnancy. It may cause harm to an unborn baby. Consult your doctor for more details.
    It is not known whether this drug passes into breast milk. Due to the potential risk to the infant, breast-feeding while using gefitinib is not recommended.

This is not a complete list. Contact your doctor or pharmacist for more details.

PROPER STORAGE OF TYROGEF :

Store Tyrogef at 20°C to 25°C (68°F to 77°F). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Gefitinib out of the reach of children and away from pets.

TYROGEF INTERACTIONS :

    Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: “blood thinners” (warfarin), drugs which reduce stomach acid (e.g., ranitidine, cimetidine, famotidine, omeprazole, lansoprazole, rabeprazole), certain liver enzyme inhibitors (CYP 3A4 inhibitors such as ketoconazole, itraconazole, erythromycin, clarithromycin), vinorelbine, NSAIDs (such as ibuprofen, naproxen), corticosteroids (such as prednisone).
    Some liver enzyme inducer medications such as rifamycins (e.g., rifampin, rifabutin), St. John’s wort or phenytoin will stimulate certain liver enzymes (CYP 3A4). Your dosage of gefitinib may need to be increased if you are using such medications. Consult your doctor or pharmacist for more details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

WHAT IS VAGACYTE TABLETS?

Vagacyte 450 mg Tablet is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

USES OF VAGACYTE TABLETS:

Vagacyte Tablet is used for Cytomegalovirus infection, Retinitis and other conditions. Vagacyte Tablet may also be used for purposes not listed in this medication guide.

Vagacyte Tablet contains Valganciclovir as an active ingredient.

Vagacyte Tablet works by preventing the growth and spread of cytomegalovirus.

POSSIBLE SIDE EFFECTS:

The most possible reported side-effects of Vagacyte Tablet are back pain, dizziness, chills, loss of appetite, indigestion, and muscle spasms.

COMMON SIDE EFFECTS MAY INCLUDE:

The following is a list of possible side effects that may occur from the use of Vagacyte Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious.

Side Effects of Vagacyte are Injection site pain, Stomach pain.

DRUGS PRECAUTIONS:

Before using Vagacyte Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

Do not drive or operate machinery.

Do not start the treatment until neutrophil count is 500 cells/l, platelet count 25000/l, or hemoglobin level 8g/dl.

Monitor complete blood counts and platelet counts tests at regular intervals during treatment.

DRUGS INTERACTIONS:

If you use other drugs or over the counter products at the same time, the effects of Vagacyte Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Vagacyte Tablet may interact with the following drugs and products:

Adalimumab

Certolizumab Cimzia

Clopine

Clozapine

Clozaril

Combivir

Deferiprone

Etanercept