ABOUT BOLETRAAZ

Boletraaz is an immunosuppressant. It works by blocking the action of certain blood cells in the immune system that may cause the body to reject the transplanted organ.

MEDICINE USES :

Boletraaz is used with other medications (such as cyclosporine) to prevent rejection of a kidney transplant. Everolimus is also used with other medications (such as tacrolimus) to prevent rejection of a liver transplant.

EVEROLIMUS COMMON SIDE EFFECTS :

Constipation, headache, nausea, and sores in the mouth/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: swelling hands/ankles/feet, wound problems (such as infection, slow wound healing, opening of wound), decreased sexual ability (in men), chest pain/pressure, shortness of breath, unusual bruising/bleeding.

Everolimus may cause your cholesterol/triglycerides or blood sugar to increase.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

SAFETY INFORMATION (Precautions) for BOLETRAAZ EVEROLIMUS TABLETS :

    Before taking everolimus, tell your doctor or pharmacist if you are allergic to it; or to sirolimus or temsirolimus; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
    Before using this medication, tell your doctor or pharmacist your medical history, especially of: high cholesterol/triglyceride levels, any recent/current infections, diabetes, liver disease, certain hereditary enzyme problems (galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption).
    Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).
    Since this medication may increase your risk of skin cancer, avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
    Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking everolimus. Everolimus may harm an unborn baby. Ask about reliable forms of birth control while taking this medication and for 8 weeks after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
    It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for 2 weeks after stopping treatment is not recommended. Consult your doctor before breast-feeding.

MEDICATION STORAGE REQUIREMENTS :

Store at room temperature of 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light; protect from moisture.

DRUG INTERACTIONS :

Some products that may interact with this drug include: other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab), ACE inhibitors (such as captopril, lisinopril).

Other medications can affect the removal of everolimus from your body, which may affect how everolimus works. Examples include :

    azole antifungals (such as itraconazole, ketoconazole),
    boceprevir,
    cobicistat,
    macrolide antibiotics (such as clarithromycin, erythromycin),
    HIV protease inhibitors (such as atazanavir, ritonavir),
    rifamycins (such as rifabutin, rifampin),
    St. John’s wort, telaprevir, telithromycin, among others.

This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

BONDRONAT 50 MG 

Bondronat is a type of drug called a bisphosphonate. Bisphosphonates are used to treat osteoporosis. It works by slowing bone loss and allowing new bone to be formed.

MEDICINE USES :

Ibandronic is used to prevent and treat certain types of bone loss (osteoporosis). Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause, as you age, or if you take corticosteroid medications (such as prednisone) for long periods.

IBANDRONIC 50 MG COMMON SIDE EFFECTS :

Diarrhea; dizziness; headache; heartburn; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms (eg, mild fever, chills, tiredness, weakness, joint or muscle aches); nausea; pain, swelling, or redness at the injection site; stomach pain or upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; fainting; fast heartbeat; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; unusual sweating; wheezing); change in the amount of urine produced; eye pain; mouth sores; painful or difficult urination; severe bone, joint, or muscle pain (especially in the hip, groin, or thigh); severe or persistent dizziness or headache; severe or persistent heartburn or stomach pain; swelling or pain in your jaw; symptoms of low blood calcium (eg, spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes, or around your mouth); vision changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

 (Precautions) FONDRONAT IBANDRONIC TABLETS :

    Talk to your doctor about the use of weight-bearing exercises to help prevent weak bones.
    Certain fractures of the thigh bone (femur) have been reported in patients using bisphosphonates. It is not known if bisphosphonates contributed to the fractures. Contact your doctor right away if you experience hip, thigh, or groin pain. Discuss any questions or concerns with your doctor.
    Proper dental care is important while you are using Bondronat. Brush and floss your teeth and visit the dentist regularly.
    Ibandronate may interfere with certain lab or diagnostic tests that use a bone-imaging agent. Be sure your doctor and lab personnel know that you are using this medication.
    Lab tests, including bone density, kidney function, and blood calcium levels, may be performed while you use Ibandronate. These tests may be used to monitor your condition or check for side effects. Your doctor may also want to evaluate you periodically while you use this medication to assess the need to continue its treatment. Be sure to keep all doctor and lab appointments.
    PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ibandronic while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use this medicine, check with your doctor. Discuss any possible risks to your baby.

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Store Ibandronate at room temperature, 59°F to 86°F (15°C to 30°C).

DRUG INTERACTIONS :

Tell your health care provider if you are taking any other medicines, especially any of the following:

    Corticosteroids (eg, prednisone) or angiogenesis inhibitors (eg, bevacizumab) because the risk of jawbone problems may be increased

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.