ABOUT DUOVIR-N

Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells). Zidovudine belongs to a group of medications called nucleoside analogue reverse transcriptase inhibitors (NRTIs), also known as antiretrovirals. Nevirapine belongs to a class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

MEDICINE USES :

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection. Zidovudine is used in combination with other antiretroviral (ART) medicines for the treatment of human immunodeficiency virus (HIV-1) infection. Zidovudine is also indicated for use in HIV-positive pregnant (over 14 weeks) women for prevention of maternal-fetal HIV transmission (passing of infection), and for primary preventive treatment of HIV infection in new-born infants. Nevarapine is used to treat and control Human Immunodeficiency Virus (HIV-1) infection for adults, adolescents, and children of any age. It must be used along with other HIV medicines.

LAMIVUDINE/ZIDOVUDINE/NEVIRAPINE COMMON SIDE EFFECTS :

headache; nausea, diarrhea; tiredness, general ill feeling; cold symptoms such as stuffy nose, sneezing, sinus pain, cough; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and trunk).

Call your doctor at once if you have:

    low white blood cell counts–fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu        symptoms, cough, trouble breathing;
    low red blood cells (anemia)–pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
    liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for DUOVIR-N LAMIVUDINE/ZIDOVUDINE/NEVIRAPINE TABLETS :

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

    Avoid pregnancy
    Discontinue use if rapid increase in aminotransferase levels, progressive hepatomegaly, or metabolic or lactic acidosis of unknown origin
    Do not start using Nevirapine if you are allergic to it
    Do not use if you are pregnant or breastfeeding
    Do not use if you develop skin rash, blistering, mouth sores, swelling of the face, shortness of breath, muscle or joint pain or general feelings of illness
    Have diabetes and renal impairment

MEDICATION STORAGE REQUIREMENTS :

Store the tablets below 30°C (36° and 86°F).

DRUG INTERACTIONS :

Duovir N Tablet may interact with the following drugs and products:

    Acyclovir
    Aspirin
    Atovaquone
    Azapropazone
    Cimetidine
    Clarithromycin

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Specification

It is
an antiviral medication used for the treatment or prevention
of Human Immunodeficiency Virus (HIV). It is not a
proper cure for HIV but it prevents the virus
from multiplying. Durart-R has two
inactive ingredients Darunavir and Ritonavir in the strength of
400mg and 50mg respectively.

Usage

• Human Immunodeficiency
  Viruses (HIV)

Strength

• Durart-R
  450mg Tablets (Contains 60 tablets in each pack)

Alternate Brands of Durart-R

• Danavir-R by
  Hetero Pharmaceuticals

• Virem-R by
  Emcure Pharmaceuticals

• All
  above and many more.

How
to take it?

It
is available in the form of tablets and for oral
use only so swallow the whole tablet in once through the
mouth with the help of water and doses as per your doctor prescribed.

How does it work?

Darunavir
& Ritonavir is a medication for
the treatment or prevention of Human Immunodeficiency
Virus (HIV). HIV
has not any proper cure so Darunavir and Ritonavir tablets
only prevent the reproduction of the virus.

Common Side-effects

• Diarrhea

• Rash

• Headaches

• Allergic
  Reactions

• Nausea

• Liver
  Problem

• Abdominal
  Pain

• Above
  all and many more

So,
if you go through any of the above effects consult with your
doctor promptly.

Attention
to Pay:

1. Don’t
   take it without any prescription of an expert doctor or pharmacist.

2. It
   is not much harmful during pregnancy
   and breastfeeding period but consult
   with your doctor before consuming it.

3. Don’t
   use this medicine if you are allergic to Darunavir
   and Ritonavir or any other inactive ingredients present
   in medicine.

4. Don’t damage
   the tablet before swelling it because
   it may damage its effectivity or strength.

5. Don’t
   take this medicine if
   you are a liver patient.

6. Children or patients under
   18 years are not recommended for use.

WHAT IS EGYMELAN?

EGYMELAN 50mg is one of a group of drugs called alkylating agents. It
sticks to one of the cancer cell’s DNA strands. DNA is the genetic code that is
in the nucleus of all animal and plant cells. It controls everything the cell
does. The cell cannot then grow and divide into 2 new cells.

MEDICINE USES :

Melphalan is used to treat multiple myeloma (a type of blood cancer),
advanced breast cancer and cancer of the ovary. This medicine treats only the
symptoms of ovarian cancer or multiple myeloma, but does not treat cancer
itself.

MELPHALAN COMMON SIDE
EFFECTS :

missed menstrual periods; weakness; or temporary hair loss.

Call your doctor at once if you have:

bone marrow suppression–sudden weakness or ill feeling, fever, chills,
pale skin, easy bruising or bleeding, red or pink urine, painful mouth sores,
cough, trouble breathing, feeling light-headed, rapid heart rate;

inflammation of your blood vessels–numbness or tingling, red skin rash,
unusual lumps or masses, fever, weight loss, muscle or joint pain, tired
feeling, unusual bleeding; or

liver problems – nausea, upper stomach pain, itching, loss of appetite,
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects.

SAFETY INFORMATION
(Precautions) for EGYMELAN MELPHALAN INJECTION :

Egymelan may lower the ability of your body to fight infection. Avoid
contact with people who have colds or infections. Tell your doctor if you
notice signs of infection like fever, sore throat, rash, or chills.

Do not receive a live vaccine (eg, measles, mumps) while you are taking
Melphalan. Talk with your doctor before you receive any vaccine.

Use of Egymelan may increase your risk of developing another type of
cancer. The risk may be greater if you use higher doses of this medicine or if
you use it for a longer period of time. Discuss any questions or concerns with
your doctor.

Egymelan may affect the ovaries. This may cause irregular or absent
menstrual periods and decreased fertility in some women. Discuss any questions
or concerns with your doctor.

Egymelan may affect the testicles and cause decreased fertility in some
men. This may be permanent in some patients. Discuss any questions or concerns
with your doctor.

PREGNANCY and BREAST-FEEDING: Melphalan has been shown to cause harm to
the fetus. Avoid becoming pregnant while taking it. If you think you may be
pregnant, contact your doctor. You will need to discuss the benefits and risks
of using this medicine while you are pregnant. It is unknown if Generic
Melphalan is found in breast milk. Do not breast-feed while taking it.

This is not a complete list. Ask your health care provider for more
information.

MEDICATION STORAGE
REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Tell your health care provider if you are taking any other medicines,
especially any of the following:



    Cisplatin because the risk of Melphalan’s side effects
may be increased

    Carmustine (BCNU), cyclosporine, or nalidixic acid
because serious lung, kidney, or bowel problems may occur

    Palifermin because if mouth or tongue sores develop,
they may be more severe or last longer



This may not be a complete list of all interactions that may occur. Ask
your health care provider if Melphalan may interact with other medicines that
you take.