WHAT IS EGYMELAN?

EGYMELAN 50mg is one of a group of drugs called alkylating agents. It
sticks to one of the cancer cell’s DNA strands. DNA is the genetic code that is
in the nucleus of all animal and plant cells. It controls everything the cell
does. The cell cannot then grow and divide into 2 new cells.

MEDICINE USES :

Melphalan is used to treat multiple myeloma (a type of blood cancer),
advanced breast cancer and cancer of the ovary. This medicine treats only the
symptoms of ovarian cancer or multiple myeloma, but does not treat cancer
itself.

MELPHALAN COMMON SIDE
EFFECTS :

missed menstrual periods; weakness; or temporary hair loss.

Call your doctor at once if you have:

bone marrow suppression–sudden weakness or ill feeling, fever, chills,
pale skin, easy bruising or bleeding, red or pink urine, painful mouth sores,
cough, trouble breathing, feeling light-headed, rapid heart rate;

inflammation of your blood vessels–numbness or tingling, red skin rash,
unusual lumps or masses, fever, weight loss, muscle or joint pain, tired
feeling, unusual bleeding; or

liver problems – nausea, upper stomach pain, itching, loss of appetite,
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects.

SAFETY INFORMATION
(Precautions) for EGYMELAN MELPHALAN INJECTION :

Egymelan may lower the ability of your body to fight infection. Avoid
contact with people who have colds or infections. Tell your doctor if you
notice signs of infection like fever, sore throat, rash, or chills.

Do not receive a live vaccine (eg, measles, mumps) while you are taking
Melphalan. Talk with your doctor before you receive any vaccine.

Use of Egymelan may increase your risk of developing another type of
cancer. The risk may be greater if you use higher doses of this medicine or if
you use it for a longer period of time. Discuss any questions or concerns with
your doctor.

Egymelan may affect the ovaries. This may cause irregular or absent
menstrual periods and decreased fertility in some women. Discuss any questions
or concerns with your doctor.

Egymelan may affect the testicles and cause decreased fertility in some
men. This may be permanent in some patients. Discuss any questions or concerns
with your doctor.

PREGNANCY and BREAST-FEEDING: Melphalan has been shown to cause harm to
the fetus. Avoid becoming pregnant while taking it. If you think you may be
pregnant, contact your doctor. You will need to discuss the benefits and risks
of using this medicine while you are pregnant. It is unknown if Generic
Melphalan is found in breast milk. Do not breast-feed while taking it.

This is not a complete list. Ask your health care provider for more
information.

MEDICATION STORAGE
REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Tell your health care provider if you are taking any other medicines,
especially any of the following:



    Cisplatin because the risk of Melphalan’s side effects
may be increased

    Carmustine (BCNU), cyclosporine, or nalidixic acid
because serious lung, kidney, or bowel problems may occur

    Palifermin because if mouth or tongue sores develop,
they may be more severe or last longer



This may not be a complete list of all interactions that may occur. Ask
your health care provider if Melphalan may interact with other medicines that
you take.