Apremilast Tablet Generic Otezla:

Aprezo Tablet is used in the treatment of moderate to severe plaque psoriasis which is a type of skin condition. This medicine is used when other conventional treatments cannot be used or if the patient is not responsive or intolerant to any of these treatments.

通用阿普司特片剂的用途:

阿普斯特片，一种磷酸二酯酶-4(PDE-4)的抑制剂，是适用于为治疗有活动性银屑病关节炎的成年患者。

Benefits of Indian Apremilast Tablets:

In Plaque psoriasis

Plaque psoriasis is the most common form of psoriasis, a condition where the skin cells in the body grow too quickly and form scales and dry patches. They can grow anywhere, but most appear on the scalp, elbows, knees, and lower back. Aprezo Tablet reduces the scaly, itchy patches which may develop on the different parts of the body. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side-Effects of Aprazo Tablets:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them:

Diarrhea.

Vomiting.

Nausea.

Weight loss.

Back pain

How to Glenmark Apremilast Tablet Work?

Aprezo Tablet is a phosphodiesterase 4 (PDE4) inhibitor. It works by blocking the action of certain chemical messengers that are responsible for inflammation associated with psoriatic arthritis and psoriasis, and thereby reduces the signs and symptoms of these conditions.

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ARAVA Leflunomide 

Arava is a pyrimidine synthesis inhibitor. It is thought to work by blocking certain enzymes responsible for abnormal tissue development or growth.

MEDICINE USES :

Aventis Leflunomide is used for treating rheumatoid arthritis by reducing signs and symptoms, improving physical function, and preventing the development of structural damage to the joints.

ARAVA LEFLUNOMIDE  SIDE EFFECTS :

                       ·        
Diarrhea;

·        
Nausea, upset
stomach;

·        
Abnormal liver
function tests;

·        
Headache;

·        
Cold symptoms
such as stuffy nose, sneezing, sore throat;

·        
Rash;

·        
Thinning hair

·        
Fever, swollen
glands, body aches, flu symptoms;

·        
Pale skin, easy
bruising or bleeding;

·        
Numbness,
tingling, or burning pain in your hands or feet;

·        
Upper stomach
pain, loss of appetite, dark urine, jaundice;

·        
New or worsening
cough with fever, trouble breathing;

·        
Severe skin
reaction, fever, swelling in your face or tongue, burning in your eye, skin                                   

·        
Pain, followed by
a red or purple skin rash that spreads especially in the face or upper body

·        
Causes blistering
and peeling.

ARAVA LEFLUNOMIDE TABLETS PRECAUTIONS :

·        
Drinking alcohol
while you are taking Arava may increase the risk of liver problems. Talk with
your doctor before drinking alcohol while taking this medicine.

·        
The safety of
Arava in patients with inactive TB has not been confirmed. You may need to have
a TB skin test before you start Leflunomide to determine if you have TB
infection. Discuss any questions or concerns with your doctor.

·        
 Serious and
sometimes fatal liver problems have been reported with Arava. Contact your
doctor right away if you develop symptoms such as dark urine, pale stools,
yellowing of the skin or eyes, stomach pain, severe or persistent nausea
or loss of appetite, or unusual tiredness.

·        
Lab tests,
including liver function, blood pressure, and complete blood cell counts, may
be performed to monitor your progress or check for side effects. Be sure to
keep all doctor and lab appointments.

·        
 PREGNANCY
and BREAST-FEEDING: Do not use this medication if you are pregnant. It may
cause birth defects or fetal death. You must have a negative pregnancy test
before you start treatment with Leflunomide.

·        
Do no become
pregnant while you are taking it. It is not known if this medicine is found in
breast milk. Do not breast-feed while taking this medicine.

STORAGE REQUIREMENTS :

Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F).

DRUG INTERACTIONS :

Tell your health care provider if you are taking any other medicines, especially any of the following:

    Methotrexate because the risk of liver problems, blood problems, or infection may be increased
    Rifampin or teriflunomide because they may increase the risk of Leflunomide’s side effects
    Anticoagulants (eg, warfarin) because the risk of its side effects, including bleeding, may be increased by Leflunomide
    Medicines that may suppress the immune system because the risk of infection or unusual bruising or bleeding may be increased. Ask your doctor if you are unsure if any of your medicines may suppress the immune system
    Medicines that may cause nerve problems, because the risk of a certain nerve side effect (burning, numbness, or tingling sensation) may be increased. Ask your doctor if you are unsure if any of you medicines may cause nerve problems
    Cholestyramine because it may decrease Leflunomide’s effectiveness
    Medicines that may harm the liver (eg, acetaminophen, methotrexate, ketoconazole, isoniazid, certain medicines for HIV infection) because the risk of liver side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the liver

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.