ADRIAMYCIN Doxorubicin
Injection:

Adriamycin is a cancer medication that interferes with the
growth and spread of cancer cells in the body. It is classified as an antitumor
antibiotic. Antitumor antibiotics are made from natural products produced by
species of the soil fungus Streptomyces. These drugs act during multiple phases
of the cell cycle and are considered cell-cycle specific.

MEDICINE USES :

Doxorubicin is used for the various treatments like Acute
lymphoblastic leukemia (ALL), Acute myeloblastic leukemia (AML), Bone sarcoma,
Breast cancer, Endometrial cancer, Gastric cancer, Head and neck cancer,
Hodgkin lymphoma, Non-Hodgkin lymphoma, Liver cancer, Kidney cancer, Multiple
myeloma, Neuroblastoma, Ovarian cancer, Small Cell Lung cancer, Soft tissue
sarcoma, Thyomas, Thyroid cancer, Transitional cell bladder cancer, Uterine
sarcoma, Wilms’ tumor and Waldenström macroglobulinemia

DOXORUBICIN COMMON SIDE EFFECTS:

Missed menstrual periods; darkening of your skin or nails;
temporary hair loss; feeling weak or tired; mild nausea, diarrhea; or eye
redness, puffy eyelids.

Call your doctor at once if you have:

 feeling short of breath
(even with mild exertion), swelling, rapid weight gain; fever, chills, body
aches, flu symptoms, sores in your mouth and throat; pale skin, easy bruising,
unusual bleeding, feeling like you might pass out;
chest pain, sudden cough, cough with foamy mucus, rapid
breathing, coughing up blood; lower back pain, blood in your urine, little or
no urinating;
Doxorubicin may cause your urine to turn a reddish-orange
color. This side effect by itself is usually not harmful. However, call your
doctor if you also have upper stomach pain, clay-colored stools, or jaundice
(yellowing of your skin or the whites of your eyes).

Call your doctor for medical advice about side effects.

ADRIAMYCIN DOXORUBICIN INJECTION PRECAUTIONS :

·        
Before
using Adriamycin, tell your doctor or pharmacist if you are allergic to it; or
to lincomycin; or if you have any other allergies. This product may contain
inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.

·        
Before
using this medication, tell your doctor or pharmacist your medical history,
especially of: a current infection, low blood cell counts (e.g., anemia,
neutropenia, thrombocytopenia), gout, heart problems (e.g., recent heart
attack, heart failure, irregular heartbeat), a history of receiving any
anthracycline-type drug (e.g., Adriamycin, idarubicin, daunorubicin,
mitoxantrone), kidney problems, liver disease, severe mouth sores (stomatitis),
radiation treatment (especially to the chest area).

·        
This
medication may lower sperm count or may cause abnormal sperm to form, possibly
causing infertility or birth defects. Consult your doctor for more details.

·        
This medication
can affect menstruation in females and cause premature menopause. Consult your
doctor or pharmacist for details.

·        
This
medication is not recommended for use during pregnancy. It may harm an unborn
baby. It is recommended that men and women use effective forms of birth control
(e.g., condoms and birth control pills) while being treated with this
medication and for 6 months after stopping the medication. Consult your doctor
for more details and to discuss reliable forms of birth control.

STORAGE REQUIREMENTS:

Refrigerate unopened vials of Doxil at 2°– 8°C (36°– 46°F).
Do not freeze.

DRUG INTERACTIONS:

Medicines that may harm the liver (eg, acetaminophen,
mercaptopurine, methotrexate, ketoconazole, isoniazid, certain medicines for
HIV infection) because the risk of Doxorubicin’s side effects may be increased.
Ask your doctor if you are unsure if any of your medicines might harm the liver

This document does not contain all possible interactions.
Keep a list of all your medications with you, and share the list with your
doctor and pharmacist.

产品介绍:

阿法替尼于2013年7月在美国上市，之后陆续在全球70多个国家获批用于治疗EGFR突变的非小细胞肺癌患者。临床试验数据显示，阿法替尼可明显延长EGFR突变的非小细胞肺癌患者的生存期。

 阿法替尼是第二代EGFR TKI（酪氨酸激酶抑制剂），与第一代可逆的EGFR TKI不同的是，阿法替尼会不可逆地与EGFR结合，从而达到关闭癌细胞信号通路、抑制肿瘤生长的目的。

 阿法替尼是第一个也是唯一一个与最好的化疗方案相比可延长最常见EGFR突变类型肺癌患者生存的TKI7-8，对一线化疗或者第一代TKI治疗（即易瑞沙、凯美纳或特罗凯）治疗失败的病人，能显著改善无进展生存期。

 阿法替尼（中文商品名吉泰瑞）于2017年2月已获中国药管局（CFDA）批准进口。此前，该药在70多个国家被批准用于治疗EGFR突变阳性非小细胞肺癌患者，并在多个国家成为了EGFR靶向药物的首选。

 阿法替尼在2016年分别获得美国FDA和欧盟批准用于治疗铂类化疗时或化疗后病情恶化的晚期肺鳞状细胞癌患者。

 碧康制药生产的Afanix是该药在全球的首仿药，也是迄今为止唯一获得政府监管机构批准合法生产的仿制药。

碧康制药由欧洲财团参与投资，是南亚地区唯一执行欧盟技术规范，并且在孟加拉两大证券交易所主板上市的大型制药企业，产品符合欧洲药典和美国药典标准。

相比其他来源不清晰的所谓同一种仿制药，即使其主要成份含量与碧康产品相接近，但由于不具备严格规范的GMP标准生产场所和政府部门的严格监管，其产品中影响药物吸收率的溶出度和生物利用度也与碧康产品具有很大差异。

 为保证用药安全，敬请谨慎选择！

适应症:

适用于晚期EGFR基因突变非小细胞肺癌的治疗和HER2阳性的晚期乳腺癌患者。阿法替尼是一种口服药物，是表皮生长因子受体(EGFR)和人表皮受体2(HER2)酪氨酸激酶的不可逆抑制剂，是第二代EGFR靶向药物。

适用于用于治疗铂类化疗时或化疗后病情恶化的晚期肺鳞状细胞癌患者。

用法与用量:

阿法替尼的推荐剂量是40mg/天，每天1次，直至疾病进展或患者无较长耐受。 口服，空腹服用，至少餐前1小时或餐后2小时服用。

ABOUT AFINITOR

AFINITOR is an immunosuppressant. It works by blocking the
action of certain blood cells in the immune system that may cause the body to
reject the transplanted organ.

MEDICINAL
USES

AFINITOR is used with other medications (such as
cyclosporine) to prevent rejection of a kidney transplant. Everolimus is also
used with other medications (such as tacrolimus) to prevent rejection of a
liver transplant.

AFINITOR COMMON SIDE EFFECTS:

·        
Constipation, headache, nausea, and sores in the
mouth/throat may occur. If any of these effects persist or worsen, tell your
doctor or pharmacist promptly.

·        
Tell your doctor right away if you have any
serious side effects, including: swelling hands/ankles/feet, wound problems such
as infection, slow wound healing, opening of wound.

·        
Decreased sexual ability (in men), chest
pain/pressure, shortness of breath, unusual bruising/bleeding.

·        
Everolimus may cause your
cholesterol/triglycerides or blood sugar to increase.

AFINITOR PRECAUTIONS:

·        Before taking everolimus, tell your doctor or
pharmacist if you are allergic to it; or to sirolimus or temsirolimus; or if
you have any other allergies. This product may contain inactive ingredients,
which can cause allergic reactions or other problems. Talk to your pharmacist
for more details.

·        Before using this medication, tell your doctor or
pharmacist your medical history, especially of: high cholesterol/triglyceride
levels, any recent/current infections, diabetes, liver disease, certain
hereditary enzyme problems (galactose intolerance, Lapp lactase deficiency,
glucose-galactose malabsorption).

·        Do not have immunizations/vaccinations
without the consent of your doctor. Avoid contact with people who have recently
received live vaccines (such as flu vaccine inhaled through the nose).

·        Since this medication may increase your risk of
skin cancer, avoid prolonged sun exposure, tanning booths, and sunlamps. Use a
sunscreen and wear protective clothing when outdoors.

·        Tell your doctor if you are pregnant or plan to
become pregnant. You should not become pregnant while you are taking
everolimus. Everolimus may harm an unborn baby.

·        
Ask about reliable forms of birth control while
taking this medication and for 8 weeks after stopping treatment. If you become
pregnant, talk to your doctor right away about the risks and benefit of this medication. It is unknown if this medication passes into
breast milk. Because of the possible risk to the infant, breast-feeding while
using this drug and for 2 weeks after stopping treatment is not recommended.
Consult your doctor before breast-feeding.

STORAGE REQUIREMENTS:

Store at room temperature of 25°C (77°F); excursions
permitted to 15°C to 30°C (59°F to 86°F). Protect from light; protect from
moisture.

AFINITOR INTERACTIONS:

Some products that may interact with this drug include: other
drugs that weaken the immune system/increase the risk of infection (such as
natalizumab, rituximab), ACE inhibitors (such as captopril, lisinopril).

Other medications can affect the removal of everolimus from
your body, which may affect how everolimus works. Examples include :

    azole antifungals (such as itraconazole,
ketoconazole),
    boceprevir,
    cobicistat,
    macrolide antibiotics (such as
clarithromycin, erythromycin),
    HIV protease inhibitors (such as
atazanavir, ritonavir),
    rifamycins (such as rifabutin, rifampin),
    St. John’s wort, telaprevir,
telithromycin, among others.

This document does not contain all possible drug
interactions. Keep a list of all the products you use (including
prescription/nonprescription drugs and herbal products) and share it with your
doctor and pharmacist