ABOUT MEGVAL MELPHALAN INJECTION:
MEGVAL for Injection is provided as a sterile, nonpyrogenic,
solidify dried powder. Each single-utilize vial contains melphalan
hydrochloride equal to 50 mg melphalan and 20 mg povidone. MEGVAL for Injection
is reconstituted utilizing the sterile diluent gave. Every vial of sterile
diluent has sodium citrate 0.2 g, propylene glycol 6.0 ml, ethanol (96%) 0.52 ml,
and Water for Injection to an aggregate of 10 ml. It is directed by veins.
Melphalan is a bifunctional alkylating agent that is active
against selected human neoplastic diseases. Melphalan is utilized in the
treatment of cancer chemotherapeutic agents. In the chemotherapy it kills the
cancer cells and blocks their supplements to develop and spread their growth.
It is also used in:
Multiple myeloma - a cancer that develops from cells in the bone
marrow called plasma cells. Plasma cells help to fight infection and disease by
Advanced cancer of the ovaries: Ovarian cancer cells divide and multiply in an
Childhood neuroblastoma - cancer of the nervous system to a baby in
Malignant melanoma - skin cancer.
Soft tissue sarcoma - cancer of the muscle, fat, fibrous tissue, blood
vessels, or other supporting tissue of the body.
COMMON SIDE EFFECTS:
Call your doctor for medical advice about side effects.
menstrual periods; weakness; temporary hair loss.
marrow suppression: Sudden weakness or ill feeling, fever, chills, pale skin,
easy bruising or bleeding, red or pink urine, painful mouth sores, cough,
trouble breathing, feeling light-headed, rapid heart rate;
of your blood vessels: numbness or tingling, red skin rash, unusual lumps or
masses, fever, weight loss, muscle or joint pain, tired feeling, unusual
problems: nausea, upper stomach pain, itching, loss of appetite, dark urine,
clay-colored stools, jaundice.
MELPHALAN INJECTION PRECAUTIONS:
may lower the ability of your body to fight infection. Avoid contact with
people who have colds or infections. Tell your doctor if you notice signs of
infection like fever, sore throat, rash, or chills.
receive a live vaccine, while you are taking Melphalan. Talk with your doctor
before you receive any vaccine.
Megval may increase your risk of developing another type of cancer. The risk
may be greater if you use higher doses of this medicine or if you use it for a
longer period of time. Discuss any questions or concerns with your doctor.
may affect the ovaries. This may cause irregular or absent menstrual periods
and decreased fertility in some women. Discuss any questions or concerns with
may affect the testicles and cause decreased fertility in some men. This may be
permanent in some patients. Discuss any questions or concerns with your doctor.
and BREAST-FEEDING: Melphalan has been shown to cause harm to the fetus. Avoid
becoming pregnant while taking it. If you think you may be pregnant, contact
need to discuss the benefits and risks of using this medicine while you are
pregnant. It is unknown if Generic Melphalan is found in breast milk. Do not breast-feed
while taking it.
Store at 20° to 25°C (68° to 77°F).
Tell your health care provider if you are taking any other
medicines, especially any of the following:
Cisplatin because the risk of Melphalan's side effects may be
Carmustine (BCNU), cyclosporine, or nalidixic acid because
serious lung, kidney, or bowel problems may occur.
Palifermin because if mouth or tongue sores develop, they may
be more severe or last longer.